Olivia Wilde as Quorra, a program, adept warrior and confidante of Kevin Flynn in the Tron system. Flynn refers to her as his "apprentice," Flynn has imparted volumes of information to her regarding the world outside of The Grid, which she longs to experience for herself.
Beau Garrett as Gem, one of four programs known as Sirens. The Sirens operate the Grid Game armory, equipping combatants with the armor needed to compete in the games. Yaya DaCosta, Serinda Swan, and Elizabeth Mathis as the other three Sirens.